MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells.

ABSTRACT:

Background

MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that regulate gene expression at post-transcriptional level. The recent discovery of the involvement of these RNAs in the control of angiogenesis renders them very attractive in the development of new approaches for restoring the angiogenic balance. Whereas miRNA-21 has been demonstrated to be highly expressed in endothelial cells, the potential function of this miRNA in angiogenesis has never been investigated.

Methodology/principal findings

We first observed in endothelial cells a negative regulation of miR-21 expression by serum and bFGF, two pro-angiogenic factors. Then using in vitro angiogenic assays, we observed that miR-21 acts as a negative modulator of angiogenesis. miR-21 overexpression

SUBMITTER: Sabatel C 

PROVIDER: S-EPMC3037403 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature