Pervasive adaptive protein evolution apparent in diversity patterns around amino acid substitutions in Drosophila simulans.

ABSTRACT: In Drosophila, multiple lines of evidence converge in suggesting that beneficial substitutions to the genome may be common. All suffer from confounding factors, however, such that the interpretation of the evidence-in particular, conclusions about the rate and strength of beneficial substitutions-remains tentative. Here, we use genome-wide polymorphism data in D. simulans and sequenced genomes of its close relatives to construct a readily interpretable characterization of the effects of positive selection: the shape of average neutral diversity around amino acid substitutions. As expected under recurrent selective sweeps, we find a trough in diversity levels around amino acid but not around synonymous substitutions, a distinctive pattern that is not expected under alternative models. This

SUBMITTER: Sattath S 

PROVIDER: S-EPMC3037414 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature