CCR10 is important for the development of skin-specific gammadeltaT cells by regulating their migration and location.

ABSTRACT: Unlike conventional αβ T cells, which preferentially reside in secondary lymphoid organs for adaptive immune responses, various subsets of unconventional T cells, such as the γδ T cells with innate properties, preferentially reside in epithelial tissues as the first line of defense. However, mechanisms underlying their tissue-specific development are not well understood. We report in this paper that among different thymic T cell subsets fetal thymic precursors of the prototypic skin intraepithelial Vγ3(+) T lymphocytes (sIELs) were selected to display a unique pattern of homing molecules, including a high level of CCR10 expression that was important for their development into sIELs. In fetal CCR10-knockout mice, the Vγ3(+) sIEL precursors developed normally in the thymus but were defective

SUBMITTER: Jin Y 

PROVIDER: S-EPMC3037513 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature