Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp.

ABSTRACT: A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM).

SUBMITTER: Oh DC 

PROVIDER: S-EPMC3037738 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature