Dengue-2 structural proteins associate with human proteins to produce a coagulation and innate immune response biased interactome.

ABSTRACT:

Background

Dengue virus infection is a public health threat to hundreds of millions of individuals in the tropical regions of the globe. Although Dengue infection usually manifests itself in its mildest, though often debilitating clinical form, dengue fever, life-threatening complications commonly arise in the form of hemorrhagic shock and encephalitis. The etiological basis for the virus-induced pathology in general, and the different clinical manifestations in particular, are not well understood. We reasoned that a detailed knowledge of the global biological processes affected by virus entry into a cell might help shed new light on this long-standing problem.

Methods

A bacterial two-hybrid screen using DENV2 structural proteins as bait was performed, and the results were u

SUBMITTER: Folly BB 

PROVIDER: S-EPMC3037883 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature