Pre-processing and differential expression analysis of Agilent microRNA arrays using the AgiMicroRna Bioconductor library.

ABSTRACT:

Background

The main research tool for identifying microRNAs involved in specific cellular processes is gene expression profiling using microarray technology. Agilent is one of the major producers of microRNA arrays, and microarray data are commonly analyzed by using R and the functions and packages collected in the Bioconductor project. However, an analytical package that integrates the specific characteristics of microRNA Agilent arrays has been lacking.

Results

This report presents the new bioinformatic tool AgiMicroRNA for the pre-processing and differential expression analysis of Agilent microRNA array data. The software is implemented in the open-source statistical scripting language R and is integrated in the Bioconductor project (http://www.bioconductor.org) under the

SUBMITTER: Lopez-Romero P 

PROVIDER: S-EPMC3037903 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature