Development and prevention of postsurgical adhesions in a chimeric mouse model of experimental endometriosis.

ABSTRACT:

Objective

To examine the impact of a recent surgery on development of endometriosis-related adhesions in a chimeric model and to determine the therapeutic efficacy of pioglitazone (PIO).

Design

Human endometrial biopsies were maintained in E(2) with or without PIO for 24 h before intraperitoneal injection into immunocompromised mice also treated with or without PIO at multiple time points after peritoneal surgery. The presence and extent of adhesions were examined in animals relative to the initial establishment of experimental endometriosis.

Setting

Medical school research center.

Patient(s)

Endometrial biopsies for experimental studies were provided by normally cycling women without a medical history indicative of endometriosis or adhesions.

Intervention(s

SUBMITTER: Herington JL 

PROVIDER: S-EPMC3038191 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature