Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients.

ABSTRACT:

Background and objective

Warfarin is a commonly used oral anticoagulant with a narrow therapeutic index and various genetic and clinical factors that influence interpatient variability in dose requirements. This study investigated the impact of genetic and nongenetic factors on warfarin dose requirements in Egyptians.

Methods

DNA was extracted from 207 patients taking warfarin for more than 2 months and genotyped for VKORC1 (3673 G>A), CYP2C9 *2*3*4*5*8, CYP4F2 (V33M; rs2108622), APOE (rs429358, rs7412), and CALU(rs339097) gene polymorphisms. Linear regression modeling was conducted to identify the genetic and nongenetic factors that independently influence warfarin dose requirements.

Results

VKORC1 3673 AA or GA genotype (P<0.0001), one or two variant alleles of CYP2

SUBMITTER: Shahin MH 

PROVIDER: S-EPMC3038469 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature