PVALB, a new Hurthle adenoma diagnostic marker identified through gene expression.

ABSTRACT:

Context

A better means to accurately identify malignant thyroid nodules and to distinguish them from benign tumors is needed. We previously identified markers for detecting thyroid malignancy, with sensitivity estimated at or close to 100%. One lingering problem with these markers was that false positives occurred with Hürthle cell adenomas (HCA) which lowered test specificity.

Methods

To locate accurate diagnostic markers, we profiled in depth the transcripts of a HCA and a Hürthle cell carcinoma (HCC). From 1146 differentially expressed genes, 18 transcripts specifically expressed in HCA were tested by quantitative PCR in a wide range of thyroid tumors (n = 76). Sensibility and specificity were calculated using receiver operating characteristic (ROC). Selected markers were

SUBMITTER: Cerutti JM 

PROVIDER: S-EPMC3038489 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature