Ontology highlight
ABSTRACT:
SUBMITTER: Das S
PROVIDER: S-EPMC3038671 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Das Saumya S Makino Seiko S Melman Yonathan F YF Shea Marisa A MA Goyal Sanjeev B SB Rosenzweig Anthony A Macrae Calum A CA Ellinor Patrick T PT
Heart rhythm 20090415 8
<h4>Background</h4>Mutations in several ion channel genes have been reported to cause rare cases of familial atrial fibrillation (AF).<h4>Objective</h4>The purpose of this study was to determine the genetic basis for AF in a family with autosomal dominant AF.<h4>Methods</h4>Family members were evaluated by 12-lead ECG, echocardiogram, signal-averaged P-wave analysis, and laboratory studies. Fourteen family members in AF-324 were studied. Six individuals had AF, with a mean age at onset of 32 yea ...[more]