PNAC: a protein nucleolar association classifier.

ABSTRACT:

Background

Although primarily known as the site of ribosome subunit production, the nucleolus is involved in numerous and diverse cellular processes. Recent large-scale proteomics projects have identified thousands of human proteins that associate with the nucleolus. However, in most cases, we know neither the fraction of each protein pool that is nucleolus-associated nor whether their association is permanent or conditional.

Results

To describe the dynamic localisation of proteins in the nucleolus, we investigated the extent of nucleolar association of proteins by first collating an extensively curated literature-derived dataset. This dataset then served to train a probabilistic predictor which integrates gene and protein characteristics. Unlike most previous experimental a

SUBMITTER: Scott MS 

PROVIDER: S-EPMC3038921 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature