Two classes of new peptaibols are synthesized by a single non-ribosomal peptide synthetase of Trichoderma virens.

ABSTRACT: Peptaibols are a group of small peptides having a high α-aminoisobutyric acid (Aib) content and produced by filamentous fungi, especially by the members of the genus Trichoderma (anamorph Hypocrea). These antibiotics are economically important for their anti-microbial and anti-cancer properties as well as ability to induce systemic resistance in plants against microbial invasion. In this study we present sequences of two classes (11-residue and 14-residue) of peptaibols produced by the biocontrol fungus Trichoderma virens. Of the 35 11-residue peptaibols sequenced, 18 are hitherto not described, and all the 53 14-residue sequences described by us here are new. We have also identified a peptaibol synthetase (non-ribosomal peptide synthetase, NRPS) with 14 complete modules in the genome of t

SUBMITTER: Mukherjee PK 

PROVIDER: S-EPMC3039350 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature