Recent human evolution has shaped geographical differences in susceptibility to disease.

ABSTRACT:

Background

Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of published association studies.

Results

We report three main findings. First, contrary to previous results, genes associated to complex diseases present lower degrees of genetic differen

SUBMITTER: Marigorta UM 

PROVIDER: S-EPMC3039608 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature