Mapping protein interactions between Dengue virus and its human and insect hosts.

ABSTRACT:

Background

Dengue fever is an increasingly significant arthropod-borne viral disease, with at least 50 million cases per year worldwide. As with other viral pathogens, dengue virus is dependent on its host to perform the bulk of functions necessary for viral survival and replication. To be successful, dengue must manipulate host cell biological processes towards its own ends, while avoiding elimination by the immune system. Protein-protein interactions between the virus and its host are one avenue through which dengue can connect and exploit these host cellular pathways and processes.

Methodology/principal findings

We implemented a computational approach to predict interactions between Dengue virus (DENV) and both of its hosts, Homo sapiens and the insect vector Aedes aegypt

SUBMITTER: Doolittle JM 

PROVIDER: S-EPMC3039688 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature