Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

ABSTRACT:

Objective

To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease.

Design

Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries.

Participants

194 418 participants, including 46 557 patients with prevalent or incident coronary heart disease. Information was available on four CRP gene tagging single nucleotide polymorphisms (rs3093077, rs1205, rs1130864, rs1800947), concentration of C reactive protein, and levels of other risk factors.

Main outcome measures

Risk ratios for coronary heart disease associated with genetically raised C reactive protein versus risk ratios with equivalent differences in C reactive protein concent

SUBMITTER: C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC) 

PROVIDER: S-EPMC3039696 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature