Molecular subtyping of DCIS: heterogeneity of breast cancer reflected in pre-invasive disease.

ABSTRACT:

Background

Molecular profiling has identified at least four subtypes of invasive breast carcinoma, which exhibit distinct clinical behaviour. There is good evidence now that DCIS represents the non-obligate precursor to invasive breast cancer and therefore it should be possible to identify similar molecular subtypes at this stage. In addition to a limited five-marker system to identify molecular subtypes in invasive breast cancer, it is evident that other biological molecules may identify distinct tumour subsets, though this has not been formally evaluated in DCIS.

Methods

Tissue microarrays were constructed for 188 cases of DCIS. Immunohistochemistry was performed to examine the expression patterns of oestrogen receptor (ER), progesterone receptor (PR), Her2, EGFR, cytokera

SUBMITTER: Clark SE 

PROVIDER: S-EPMC3039794 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature