Non-alcoholic fatty liver disease proteomics.

ABSTRACT:

Purpose

Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver injury that has gained concern in clinical hepatology. The principal aim of this study was to find differences in protein expression between patients with NAFLD and healthy controls.

Experimental design

Changes in protein expression of liver samples from each of the three groups of subjects, controls, non-alcoholic steatosis, and non-alcoholic steatohepatitis (NASH), were analyzed by DIGE combined with MALDI TOF/TOF analysis, a proteomic approach that allows to compare hundreds of proteins simultaneously.

Results

Forty-three proteins exhibiting significant changes (ratio ≥1.5, p<0.05) were characterized, 22 comparing steatosis samples versus control samples and 21 comparing NASH v

SUBMITTER: Rodriguez-Suarez E 

PROVIDER: S-EPMC3040121 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature