Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis.

ABSTRACT:

Background

The notion that genes are non-randomly organized within the chromosomes of eukaryotic organisms has recently received strong experimental support. Clusters of co-expressed and co-localized genes have been recognized as playing key roles in a number of functional pathways and adaptive responses including organism development, differentiation, disease states and aging. The identification of genes arranged in close proximity with each other within a particular temporal and spatial transcriptional program is anticipated to unravel possible functional links and reciprocal interactions.

Results

We developed a novel software tool Gepoclu (Gene Positional Clustering) that automatically selects genes based on expression values from multiple sources, including microarray, E

SUBMITTER: Dottorini T 

PROVIDER: S-EPMC3040130 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature