Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development.

ABSTRACT:

Background

Leprosy is a chronic infectious disease caused by Mycobacterium leprae that can manifest a wide variety of immunological and clinical outcomes ranging from potent humoral responses among borderline lepromatous (BL) and lepromatous (LL) patients to strong cellular responses among tuberculoid (TT) and borderline tuberculoid (BT) patients. Until recently, relatively little has been known about the immune responses to individual proteins of M. leprae recognized during leprosy.

Methods

The immune reactivity to a panel of 33 M. leprae recombinant proteins was evaluated among leprosy patients and controls from a high endemic area for leprosy (Goiania/GO, Central Brazil). Serum IgG responses were measured by ELISA (45 participants/group) and T cell responses (20 participa

SUBMITTER: Sampaio LH 

PROVIDER: S-EPMC3040138 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature