The Trypanosoma cruzi Sylvio X10 strain maxicircle sequence: the third musketeer.

ABSTRACT:

Background

Chagas disease has a diverse pathology caused by the parasite Trypanosoma cruzi, and is indigenous to Central and South America. A pronounced feature of the trypanosomes is the kinetoplast, which is comprised of catenated maxicircles and minicircles that provide the transcripts involved in uridine insertion/deletion RNA editing. T. cruzi exchange genetic material through a hybridization event. Extant strains are grouped into six discrete typing units by nuclear markers, and three clades, A, B, and C, based on maxicircle gene analysis. Clades A and B are the more closely related. Representative clade B and C maxicircles are known in their entirety, and portions of A, B, and C clades from multiple strains show intra-strain heterogeneity with the potential for maxicircle ta

SUBMITTER: Ruvalcaba-Trejo LI 

PROVIDER: S-EPMC3040149 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature