General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq.

ABSTRACT:

Background

Species with heteromorphic sex chromosomes face the challenge of large-scale imbalance in gene dose. Microarray-based studies in several independent male heterogametic XX/XY systems suggest that dosage compensation mechanisms are in place to mitigate the detrimental effects of gene dose differences. However, recent genomic research on female heterogametic ZZ/ZW systems has generated surprising results. In two bird species and one lepidopteran no evidence for a global dosage compensating mechanism has been found. The recent advent of massively parallel RNA sequencing now opens up the possibility to gauge the generality of this observation with a broader phylogenetic sampling. It further allows assessing the validity of microarray-based inference on dosage compensation wit

SUBMITTER: Wolf JB 

PROVIDER: S-EPMC3040151 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature