Prostate cancer susceptibility Loci identified on chromosome 12 in African Americans.

ABSTRACT: Prostate cancer (PCa) is a complex disease that disproportionately affects African Americans and other individuals of African descent. A number of regions across the genome have been associated to PCa, most of them with moderate effects. A few studies have reported chromosomal changes on 12p and 12q that occur during the onset and development of PCa but to date no consistent association of the disease with chromosome 12 polymorphic variation has been identified. In order to unravel genetic risk factors that underlie PCa health disparities we investigated chromosome 12 using ancestry informative markers (AIMs), which allow us to distinguish genomic regions of European or West African origin, and tested them for association with PCa. Additional SNPs were genotyped in those areas where signif

SUBMITTER: Bonilla C 

PROVIDER: S-EPMC3040176 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature