Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC3040219 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Yang Ji J Yang Xue X Chu Yiwei Y Li Ming M
PloS one 20110216 2
T(H)17 cells have been implicated in a growing list of inflammatory disorders. Antagonism of T(H)17 cells can be used for the treatment of inflammatory injury. Currently, very little is known about the natural compound controlling the differentiation of T(H)17 cells. Here, we showed that Baicalin, a compound isolated from a Chinese herb, inhibited T(H)17 cell differentiation both in vitro and in vivo. Baicalin might inhibit newly generated T(H)17 cells via reducing RORγt expression, and together ...[more]