Androgen-induced cell migration: role of androgen receptor/filamin A association.

ABSTRACT:

Background

Androgen receptor (AR) controls male morphogenesis, gametogenesis and prostate growth as well as development of prostate cancer. These findings support a role for AR in cell migration and invasiveness. However, the molecular mechanism involved in AR-mediated cell migration still remains elusive.

Methodology/principal findings

Mouse embryo NIH3T3 fibroblasts and highly metastatic human fibrosarcoma HT1080 cells harbor low levels of transcriptionally incompetent AR. We now report that, through extra nuclear action, AR triggers migration of both cell types upon stimulation with physiological concentrations of the androgen R1881. We analyzed the initial events leading to androgen-induced cell migration and observed that challenging NIH3T3 cells with 10 nM R1881 rapidl

SUBMITTER: Castoria G 

PROVIDER: S-EPMC3040221 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature