Iodine deficiency in northern Paris area: impact on fetal thyroid mensuration.
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ABSTRACT: Introduction
Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation.Materials and methods
110 patients underwent several determinations of urinary iodine excretion (UIE) and of serum FT4, FT3, and TSH. Fetal thyroid gland size was assessed using ultrasonography.Results
We found evidence of widespread iodine deficiency (mean UIE, 49.8 µg/L [standard deviation, 2.11]). Iodine deficiency did not correlate significantly with maternal thyroid parameters but showed a significant negative correlation with fetal thyroid gland size (rho = 0.25, P = 0.02).Conclusion
Iodine deficiency during pregnancy is still a problem in our geographical area and affects the fetal thyroid gland. Clinical Trials.gov NCT00162539.
SUBMITTER: Luton D
PROVIDER: S-EPMC3040245 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Iodine deficiency in northern Paris area: impact on fetal thyroid mensuration.
Luton Dominique D Alberti Corinne C Vuillard Edith E Ducarme Guillaume G Oury Jean François JF Guibourdenche Jean J
PloS one 20110216 2
<h4>Introduction</h4>Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation.<h4>Materials and methods</h4>110 patients underwent several determinations of urinary iodine excretion (UIE) and of serum FT4, FT3, and TSH. Fetal thyroid gland size was assessed using ultrasonography.<h4>Results</h4>We found evidence of widespread iodine deficien ...[more]
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2010-11-04 | E-GEOD-25144 | biostudies-arrayexpress
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