Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking.

ABSTRACT:

Rationale

Adipose-derived stem cells express multiple growth factors that inhibit endothelial cell apoptosis, and demonstrate substantial pulmonary trapping after intravascular delivery.

Objectives

We hypothesized that adipose stem cells would ameliorate chronic lung injury associated with endothelial cell apoptosis, such as that occurring in emphysema.

Methods

Therapeutic effects of systemically delivered human or mouse adult adipose stem cells were evaluated in murine models of emphysema induced by chronic exposure to cigarette smoke or by inhibition of vascular endothelial growth factor receptors.

Measurements and main results

Adipose stem cells were detectable in the parenchyma and large airways of lungs up to 21 days after injection. Adipose stem cell trea

SUBMITTER: Schweitzer KS 

PROVIDER: S-EPMC3040390 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature