Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth.

ABSTRACT:

Rationale

Glutathione plays an important role in antioxidant and inflammatory processes in the lung. Alterations in glutathione metabolism are a central feature of several chronic lung diseases.

Objectives

To determine whether sequence variation in genes in the glutathione synthesis pathway alters susceptibility to air pollution effects on lung function.

Methods

In this prospective study, 14,821 lung function measurements were taken on 2,106 children from 12 Southern California cities. Tagging single-nucleotide polymorphisms in glutathione metabolism pathway genes GSS, GSR, GCLM, and GCLC were genotyped by GoldenGate assay (Illumina, San Diego, CA). Mixed regression models were used to determine whether particular haplotypes were associated with FEV(1), maximal mid-ex

SUBMITTER: Breton CV 

PROVIDER: S-EPMC3040392 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature