Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema.

ABSTRACT:

Rationale

chronic obstructive pulmonary disease (COPD), characterized by airflow limitation, is a disorder with high phenotypic and genetic heterogeneity. Pulmonary emphysema is a major but variable component of COPD; familial data suggest that different components of COPD, such as emphysema, may be influenced by specific genetic factors.

Objectives

to identify genetic determinants of emphysema assessed through high-resolution chest computed tomography in individuals with COPD.

Methods

we performed a genome-wide association study (GWAS) of emphysema determined from chest computed tomography scans with a total of 2,380 individuals with COPD in three independent cohorts of white individuals from (1) a cohort from Bergen, Norway, (2) the Evaluation of COPD Longitudinally

SUBMITTER: Kong X 

PROVIDER: S-EPMC3040393 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature