Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.

ABSTRACT: The local progenitor population in the olfactory bulb (OB) gives rise to mitral and tufted projection neurons during embryonic development. In contrast, OB interneurons are derived from sources outside the bulb where neurogenesis continues throughout life. While many of the genes involved in OB interneuron development have been characterized, the genetic pathways driving local progenitor cell differentiation in this tissue are largely unknown. To better understand this process, we used transcriptional profiling to monitor gene expression of whole OB at daily intervals from embryonic day 11 through birth, generating a compendium of gene expression encompassing the major developmental events of this tissue. Through hierarchical clustering, bioinformatics analysis, and validation by RNA in si

SUBMITTER: Campbell GR 

PROVIDER: S-EPMC3040421 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature