Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement.

ABSTRACT:

Aims

To confirm and extend to primary care settings prior genome-wide association results that distinguish smokers who successfully quit from individuals who were not able to quit smoking in clinical trials.

Materials & methods

Affymetrix 6.0 Arrays were used to study DNA from successful quitters and matched individuals who did not quit from the Patch in Practice study of 925 smokers in 26 UK general practices who were provided with 15 mg/16 h nicotine-replacement therapy and varying degrees of behavioral support.

Results

Only a few SNPs provided results near 'genome-wide' levels of significance. Nominally significant (p < 0.01) SNP results identify the same chromosomal regions identified by prior genome-wide association studies to a much greater extent than expected

SUBMITTER: Uhl GR 

PROVIDER: S-EPMC3040594 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature