Genetic, biochemical, and environmental factors associated with pregnancy outcomes in newborns from the Czech Republic.

ABSTRACT:

Background

Oxidative damage to placental DNA can result in negative pregnancy outcomes, including intrauterine growth restriction (IUGR) and low birth weight (LBW).

Objective

We investigated associations between the levels of 8-oxo-7,8-dihydro-2´-deoxyguanosine (8-oxodG), a marker of oxidative DNA damage, in placental DNA, exposure to air pollutants during pregnancy, genetic polymorphisms in 94 selected genes, and pregnancy outcomes.

Methods

We studied 891 newborns who were IUGR- or LBW-affected or normal weight and were born between 1994 and 1999 in the Czech Republic in two districts with different levels of air pollution.

Results

We found nonsignificantly elevated 8-oxodG levels in the IUGR-affected group compared with the non-IUGR group (p = 0.055). Similar

SUBMITTER: Rossner P 

PROVIDER: S-EPMC3040616 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature