A unified framework for multi-locus association analysis of both common and rare variants.

ABSTRACT:

Background

Common, complex diseases are hypothesized to result from a combination of common and rare genetic variants. We developed a unified framework for the joint association testing of both types of variants. Within the framework, we developed a union-intersection test suitable for genome-wide analysis of single nucleotide polymorphisms (SNPs), candidate gene data, as well as medical sequencing data. The union-intersection test is a composite test of association of genotype frequencies and differential correlation among markers.

Results

We demonstrated by computer simulation that the false positive error rate was controlled at the expected level. We also demonstrated scenarios in which the multi-locus test was more powerful than traditional single marker analysis. To ill

SUBMITTER: Shriner D 

PROVIDER: S-EPMC3040731 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature