Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B.

ABSTRACT:

Background

Salvianolic acid B (SB) is an active component isolated from Danshen, a traditional Chinese medicine widely used for the treatment of cardiovascular disorders. Previous study suggested that SB might inhibit adhesion as well as aggregation of platelets by a mechanism involving the integrin α2β1. But, the signal cascades in platelets after SB binding are still not clear.

Methodology/principal findings

In the present study, a differential proteomic analysis (two-dimensional electrophoresis) was conducted to check the protein expression profiles of rat platelets with or without treatment of SB. Proteins altered in level after SB exposure were identified by MALDI-TOF MS/MS. Treatment of SB caused regulation of 20 proteins such as heat shock-related 70 kDa protein 2 (hs

SUBMITTER: Ma C 

PROVIDER: S-EPMC3040754 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature