Teneurin C-terminal associated peptide-1 blocks the effects of corticotropin-releasing factor on reinstatement of cocaine seeking and on cocaine-induced behavioural sensitization.

ABSTRACT:

Background and purpose

The stress-related neuropeptide, corticotropin-releasing factor (CRF), has become an important focus of studies of cocaine addiction, and in particular, the effects of stress on cocaine-related behaviours. A recently discovered peptide system, the teneurin C-terminal associated peptides (TCAP), has been implicated in the regulation of the stress response, via a CRF-related mechanism. Here we have determined whether treatment with TCAP-1, a synthetic analogue of TCAP, modulated two cocaine-related behaviours induced by CRF: reinstatement of cocaine seeking, and expression of cocaine-induced behavioural sensitization.

Experimental approach

In Experiment 1, rats trained to self-administer cocaine were given acute or repeated (once daily for 5 days) i.c.v.

SUBMITTER: Kupferschmidt DA 

PROVIDER: S-EPMC3041248 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature