Propofol anesthesia and sleep: a high-density EEG study.

ABSTRACT:

Study objectives

The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia and compare them to sleep.

Design

256-channel EEG recordings in humans during propofol anesthesia.

Setting

Hospital operating room.

Patients or participants

8 healthy subjects (4 males).

Interventions

N/A.

Measurements and results

Initially, propofol induced increases in EEG power from 12-25 Hz. Loss of consciousness (LOC) was accompanied by the appearance of EEG slow waves that resembled the slow waves of NREM sleep. We compared slow waves in propofol to slow waves recorded during natural sleep and found th

SUBMITTER: Murphy M 

PROVIDER: S-EPMC3041704 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature