Task positive and default mode networks during a parametric working memory task in obstructive sleep apnea patients and healthy controls.

ABSTRACT:

Introduction

Functional magnetic resonance imaging (fMRI) studies enable the investigation of neural correlates underlying behavioral performance. We investigate the working memory (WM) function of patients with untreated obstructive sleep apnea (OSA) from the view point of task positive and default mode networks (TPN and DMN, respectively) and compare the results to those of healthy controls (HC).

Methods

A parametric fMRI experiment with 4 levels of visuospatial N-back task was used to investigate the pattern of cortical activation in 17 men with untreated moderate or severe OSA and 7 age-matched HC. Categorical and parametrical analysis of the data was performed. Multiple regression analysis of fMRI data of OSA patients was performed with AHI, nocturnal desaturation time,

SUBMITTER: Prilipko O 

PROVIDER: S-EPMC3041705 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature