Antibodies against CD20 or B-cell receptor induce similar transcription patterns in human lymphoma cell lines.

ABSTRACT:

Background

CD20 is a cell surface protein exclusively expressed on B cells. It is a clinically validated target for Non-Hodgkin's lymphomas (NHL) and autoimmune diseases. The B cell receptor (BCR) plays an important role for development and proliferation of pre-B and B cells. Physical interaction of CD20 with BCR and components of the BCR signaling cascade has been reported but the consequences are not fully understood.

Methodology

In this study we employed antibodies against CD20 and against the BCR to trigger the respective signaling. These antibodies induced very similar expression patterns of up- and down-regulated genes in NHL cell lines indicating that CD20 may play a role in BCR signaling and vice versa. Two of the genes that were rapidly and transiently induced by bo

SUBMITTER: Franke A 

PROVIDER: S-EPMC3041769 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature