DiNAMIC: a method to identify recurrent DNA copy number aberrations in tumors.

ABSTRACT:

Motivation

DNA copy number gains and losses are commonly found in tumor tissue, and some of these aberrations play a role in tumor genesis and development. Although high resolution DNA copy number data can be obtained using array-based techniques, no single method is widely used to distinguish between recurrent and sporadic copy number aberrations.

Results

Here we introduce Discovering Copy Number Aberrations Manifested In Cancer (DiNAMIC), a novel method for assessing the statistical significance of recurrent copy number aberrations. In contrast to competing procedures, the testing procedure underlying DiNAMIC is carefully motivated, and employs a novel cyclic permutation scheme. Extensive simulation studies show that DiNAMIC controls false positive discoveries in a variety

SUBMITTER: Walter V 

PROVIDER: S-EPMC3042182 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature