Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty.

ABSTRACT:

Objective

This project was designed to follow-up prior evidence that demonstrated a significant association between vitamin B12 transport and metabolism and the frailty syndrome in community-dwelling older women. The cross-sectional relationship between genetic variants within six candidate genes along this pathway with serum methylmalonic acid (MMA) levels and frailty was evaluated in this same population of older women.

Methods

Baseline measures were collected prior to folate fortification from 326 women in the Women's Health and Aging Studies I and II. Odds ratios and statistical tests were estimated for single SNP and haplotype via linear regression models for serum MMA, a marker for available vitamin B12, and in logistic regression models for frailty.

Results

Fif

SUBMITTER: Matteini AM 

PROVIDER: S-EPMC3042247 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature