Highly enantioselective Mannich reactions with α-aryl silyl ketene acetals and imines.

ABSTRACT: Mannich reactions with chiral silicon Lewis acid activated acylhydrazones and α-aryl silyl ketene acetals and α-aryl,α-alkyl silyl ketene imines proceed efficiently and with good to excellent levels of both diastereoselectivity and enantioselectivity. The reactions provide access to α-aryl,β-hydrazido esters and α-aryl,α-alkyl,β-hydrazido nitriles, which are valuable analogs of β-amino acids.

SUBMITTER: Notte GT 

PROVIDER: S-EPMC3042282 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature