A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study.

ABSTRACT:

Background

A number of single nucleotide polymorphisms (SNPs) have been associated with broadband ultrasound attenuation (BUA) and speed of sound (SOS) as measured by quantitative ultrasound (QUS) at the calcaneus in the Framingham 100K genome-wide association study (GWAS) but have not been validated in independent studies. The aim of this analysis was to determine if these SNPs are associated with QUS measurements assessed in a large independent population of European middle-aged and elderly men. The association between these SNPs and bone mineral density (BMD) measured using dual-energy X-ray absorptiometry (DXA) was also tested.

Methods

Men aged 40-79 years (N = 2960) were recruited from population registers in seven European centres for participation in an observational

SUBMITTER: Roshandel D 

PROVIDER: S-EPMC3042372 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature