Adverse events associated with treatment of latent tuberculosis in the general population.

ABSTRACT:

Background

Guidelines recommend treatment of latent tuberculosis in patients at increased risk for active tuberculosis. Studies investigating the association of therapy with serious adverse events have not included the entire treated population nor accounted for comorbidities or occurrence of similar events in the untreated general population. Our objective was to estimate the risk of adverse events requiring hospital admission that were associated with therapy for latent tuberculosis infection in the general population.

Methods

Using administrative health data from the province of Quebec, we created a historical cohort of all residents dispensed therapy for latent tuberculosis between 1998 and 2003. Each patient was matched on age, sex and postal region with two untreated r

SUBMITTER: Smith BM 

PROVIDER: S-EPMC3042475 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature