A candidate gene study revealed sex-specific association between the OLR1 gene and carotid plaque.

ABSTRACT:

Background and purpose

Sex differences have been recognized in stroke risk; however, the sex-dependent genetic contribution to stroke is unclear. We sought to examine the sex-dependent associations between genes involved in lipid metabolism and carotid atherosclerotic plaque, a subclinical precursor of stroke.

Methods

For the Genetic Determinant of Subclinical Carotid Disease study, 287 Dominicans ascertained through the Northern Manhattan Study were examined for carotid plaque using high-resolution ultrasound. Sixty-four single nucleotide polymorphisms (SNPs) in 11 lipid-related genes were genotyped. Plaque presence and plaque subphenotypes, including multiple, thick, irregular, and calcified plaque, were analyzed. First, the interaction between each SNP and sex was evaluat

SUBMITTER: Wang L 

PROVIDER: S-EPMC3042493 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature