Novel therapeutic approaches to lupus glomerulonephritis: translating animal models to clinical practice.

ABSTRACT: Systemic lupus erythematosus is a chronic autoimmune disease frequently affecting the kidney. Renal involvement is characterized by glomerular immune complex deposits and proliferative glomerulonephritis progressing to glomerulosclerosis and kidney failure. The development of systemic lupus erythematosus is regulated genetically, and lupus susceptibility genes have been linked to immune hyper-responsiveness and loss of immune regulation. In addition to the systemic immune defects, recent studies in animal models show that susceptibility to lupus nephritis is influenced by intrinsic renal factors. Thus, renal cell responses to immune-mediated glomerular injury determine disease outcome. This supports the idea that future treatments for lupus nephritis need to focus on regulating end-organ r

SUBMITTER: Bagavant H 

PROVIDER: S-EPMC3042497 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature