Highly stable, ligand-clustered "patchy" micelle nanocarriers for systemic tumor targeting.

ABSTRACT: A novel linear-dendritic block copolymer has been synthesized and evaluated for targeted delivery. The use of the dendron as the micellar exterior block in this architecture allows the presentation of a relatively small quantity of ligands in clusters for enhanced targeting, thus maintaining a long circulation time of these "patchy" micelles. The polypeptide linear hydrophobic block drives formation of micelles that carry core-loaded drugs, and their unique design gives them extremely high stability in vivo. We have found that these systems lead to extended time periods of increased accumulation in the tumor (up to 5 days) compared with nontargeted vehicles. We also demonstrate a fourfold increase in efficacy of paclitaxel when delivered in the targeted nanoparticle systems, while signific

SUBMITTER: Poon Z 

PROVIDER: S-EPMC3042519 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature