Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers.

ABSTRACT:

Background

Studying gene-environment interactions may provide insight about mechanisms underpinning the reported association between chromosome 15q24-25.1 variation and lung cancer susceptibility.

Methods

In a nested case-control study comparing 746 lung cancer cases to 1,477 controls, all of whom were non-Hispanic white smokers in the β-Carotene and Retinol Efficacy Trial, we examined whether lung cancer risk is associated with single nucleotide polymorphisms (SNPs) tagging the AGPHD1, CHRNA5, CHRNA3, and CHRNB4 genes and whether such risk is modified by diet and other characteristics. Intake of fruits and vegetables, their botanical groups, and specific nutrients were ascertained generally at baseline by food-frequency questionnaire.

Results

Several sets of SNPs in

SUBMITTER: Sakoda LC 

PROVIDER: S-EPMC3042523 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature