Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic.

ABSTRACT:

Aim

To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.

Methods

A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer. Clinical data and pathology features of the tumor were obtained from chart review.

Results

Of the 212 CRC patients recruited, 61 (29%) reported a family history of CRC, 45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC. Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients, respectively. Twenty percent of the colorectal tumors had features o

SUBMITTER: Koehler-Santos P 

PROVIDER: S-EPMC3042655 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature