Ontology highlight
ABSTRACT:
SUBMITTER: Garbati MR
PROVIDER: S-EPMC3042717 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Cancer letters 20110112 1
Human diffuse large B-cell lymphoma cell line RC-K8 has an altered EP300 locus that encodes a C-terminally truncated histone acetyltransferase (HAT) protein (p300ΔC). We now show that p300ΔC contains 1047N-terminal amino acids of p300 fused to 25 amino acids encoded by sequences from chromosome 6. Over-expressed p300ΔC localized to nuclear subdomains and interacted with transcription factor REL. p300ΔC did not function as a co-activator for REL-directed transactivation, and blocked the ability o ...[more]