Parity, early menopause and the incidence of bladder cancer in women: a case-control study and meta-analysis.

ABSTRACT:

Introduction

Incidence rates of bladder cancer are notably higher in men than in women. While there is evidence that reproductive and hormonal risk factors may influence risk of bladder cancer, data are inconclusive.

Materials and methods

We examined reproductive, menstrual and hormonal use history in our population-based case-control study of bladder cancer in New Hampshire (NH), USA (n=207 women cases and n=463 women controls). Additionally, we performed a meta-analysis of the published literature. We used unconditional logistic regression analysis to compute adjusted odds ratios associated with each risk factor in the NH study. We combined these estimates with those from the published literature using inverse variance effects models.

Results

In the NH study, a slig

SUBMITTER: Dietrich K 

PROVIDER: S-EPMC3042804 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature