Overexpression of Sterol Carrier Protein 2 in patients with hereditary cholesterol gallstones.

ABSTRACT:

Background

Lithogenic bile is the major cause of cholesterol gallstone, but its pathogenesis is not well understood. The hypersecretion of biliary cholesterol is believed to be an important cause of lithogenic bile. Sterol Carrier Protein 2 (SCP2) participates in cholesterol trafficking and lipid metabolism in hepatocytes and may play a key role in cholesterol gallstone formation.

Methods

21 cholesterol gallstone genealogies were studied to investigate the expression of SCP2 gene in liver tissue of hereditary and non-hereditary cholesterol gallstone patients as well as non-gallstone patients. The mRNA expression of liver SCP2 in 28 hereditary patients, 30 non-hereditary cholesterol gallstone patients and 32 non-gallstone patients was measured by Reverse Transcription Polymer

SUBMITTER: Cui Y 

PROVIDER: S-EPMC3042972 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature